As of November 14, 2024, the US Department of Energy (DOE) announced a $4 million federal investment in 10 projects across 8 states that will harness the processing power of the world’s most powerful supercomputers in order to solve the most complex manufacturing challenges and strengthen American manufacturing. [1] Within the DOE’s High-Performance Computing for Energy Innovation (HPC4EI) initiative, the selected teams will use advanced modeling, simulation, and data analysis to projects that enhance manufacturing efficiency, lower industrial emissions, and explore the use of new materials and processes for clean energy applications. Under the HPC4EI initiative are the High-Performance Computing for Manufacturing (HPC4Mfg) and High-Performance Computing for Materials (HPC4Mtls) programs. The former aims to help manufacturers streamline processes, increase productivity, and lower their carbon footprint. The latter focuses on developing materials that perform well in harsh environments. Both programs serve to leverage high-computing technology to help companies improve performance, increase efficiency, and achieve cost savings.